SUNDAY, JUNE 30

 

15.00 – 18.30

Registration

19.00 – 22.00

Putting up of Posters and Dinner 

 

MONDAY, JULY 1 

 

09.00 – 09.20

Opening of ESMEC 2019
Gianluca SBARDELLA – President of the Medicinal Chemistry Division of the Italian Chemical Society
Antoni TORRENS JOVER – Member of the Executive Committee of the European Federation for Medicinal Chemistry
Marco MACCHIA – Director of the European School of Medicinal Chemistry

“IMMUNO-ONCOLOGY: SMALL MOLECULES AND BEYOND”

Co-chair:
Gianluca PAPEO – Nerviano Medical Sciences, Nerviano (I)
Tracey PIRALI – University of Piemonte Orientale (I)

09.20 – 09.30

Introduction to the Session

09.30 – 10.15

Anna MONDINO – IRCCS, San Raffaele Scientific Institute, Milan (I)
Immune-oncology: recent developments and future challenges

10.15 – 11.00

Lisa KÖTZNER – Merck KGaA, Darmstadt (D)
Small molecules drive big improvements in immuno‐oncology therapies

11.00 – 11.30

Coffee Break

11.30 – 12.15

Alexander DÖMLING – University of Groningen (NL)
Form follows function: PD1-PDL1 from structure to mAbs to small molecules to macrocycles

12.15 – 13.00

Julio CASTRO-PALOMINO – Palobiofarma, Barcelona (ES)
Challenges and opportunities of adenosine modulators in Immuno-oncology

13.00 – 15.00

Lunch

15.00 – 16.30

Case Study:
Shabnam SHAABANI – University of Groningen (NL)
Miniaturized, automated and accelerated chemistry

16.30 – 18.00

Case Study:
Barbara VALSASINA – Nerviano Medical Sciences, Nerviano (I)
Solve the jigsaw puzzle and find the best ADC

20.00

Dinner

 

TUESDAY, JULY 2 

 

“PHOTOCATALYSIS IN MEDICINAL CHEMISTRY”

Co-chair:
Stefania BUTINI – University of Siena (I)
Paolo GRIECO – University of Naples (I)

09.00 – 09.15

Introduction to the Session

09.15 – 10.00

Paolo MELCHIORRE Institute of Chemical Research of Catalonia, Tarragona (ES)
Organic synthesis in the excited state

10.00 – 10.45

Geraldine MASSON – Institut de Chimie des Substances Naturelles, Gif-sur-Yvette Cedex (FR)
Visible light Photoredox Catalysis as a tool for functionalization and preparation of complex organic molecules for compound library building and scale-up process

10.45 – 11.15

Coffee Break

11.15 – 12.00

Massimo OLIVUCCI – University of Siena (I)
Recent progress in the “automated” simulation of the light-response of rod photoreceptors

12.00 – 12.45

Christopher N. JOHNSON – Astex Pharmaceuticals, Cambridge (UK)
Photoredox catalysis and automated synthesis as new enabling tools for fragment-based drug-design

12.45 – 14.30

Lunch

14.30 – 16.00

Case Study:
Paolo MELCHIORRE Institute of Chemical Research of Catalonia, Tarragona (ES)
Photoredox catalysis in medicinal chemistry endeavors

Case Study:
Christopher N. JOHNSON – Astex Pharmaceuticals, Cambridge (UK)
Fragment based drug discovery, theory and practice

16.00 – 18.30

Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
Poster Session

18.00

Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI

20.00

Dinner

 

WEDNESDAY, JULY 3 

  

“ARTIFICIAL INTELLIGENCE IN DRUG DISCOVERY AND DEVELOPMENT”

Co-chair:
Andrea CAVALLI – University of Bologna (I)
Antonio MACCHIARULO – University of Perugia (I)

09.00 – 09.15

Introduction to the Session

09.15 – 10.00

Enzo GROSSI – Villa Santa Maria Foundation, Tavernerio (I)
Big data analytics, machine learning and artificial intelligence: state of the art and future perspectives in drug discovery

10.00 – 10.45

Jürgen BAJORATH – University of Bonn (D)
Data structures for compound promiscuity analysis and machine learning

10.45 – 11.15

Coffee Break

11.15 – 12.00

Alex TROPSHA University of North Carolina, Chapel Hill, NC (USA)
AI-driven design of novel, synthetically feasible bioactive compounds

12.00 – 12.45

Roberta BURSI – InSilicoTrials Technologies, Milan (I)
Riding on the forward of a moving wave: perspectives on artificial intelligence in drug research and development

12.45 – 14.30

Lunch

14.30 – 15.30

Case Studies
Orazio NICOLOTTI – University of Bari (I)
MuSSel: a web platform for protein drug target prediction based on multi-fingerprint similarity 

15.30 – 17.30

Round Table: Medicinal Chemistry: what’s next
Chairman: Gabriele COSTANTINO – Past President of the Medicinal Chemistry Division – SCI, and Director of the Department of Food and Drugs, University of Parma
Ives AUBERSON – President of the European Federation for Medicinal Chemistry
Jurgen BAJORATH – American Chemical Society and Editor of the Journal of Medicinal Chemistry
Roberto PELLICCIARI – Tes Pharma Srl, Perugia (I)
Ulrike HOLZGRABE – American Chemical Society and Editor of the Journal of Medicinal Chemistry
Loredana BERGAMINI – Farmindustria

20.30

Social Dinner

THURSDAY, JULY 4  

 

 

Chairperson:

Antoni TORRENS JOVER – Esteve Pharmaceuticals, Barcelona (E)

09.00 – 10.00

Tiziano BANDIERA – Istituto Italiano di Tecnologia – Genova (I)
Market Watch: New Drug Approval in 2018 and Synthetic Strategies

10.00 – 10.30

Coffee break

10.30 – 12.30

Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
Selected oral lectures by participants:
– Claudia BRAGA FERNANDEZ – University of Lisbon (PT)
– Federico CAPUANA – University of Turin (I)
– Michael CLEGG – University of Strathclyde and GlaxoSmithKline R&D Stevenage (UK)
– Daniela DOLCIAMI – University of Perugia (I)
– Tuhina KHAN – University of Siena (I)
– Margherita MIELE – University of Wien (A)

12.30 – 13.15

Marco MACCHIA – University of Pisa (I) – Director of the European School of Medicinal Chemistry
Awards of Selected Posters
Concluding Remarks

13.15

Lunch and leaving