15.00 – 18.30

Registration

19.00 – 22.00

Putting up of Posters and Dinner

09.00 – 09.20

Opening of ESMEC 2018
Gabriele COSTANTINO – President of the Medicinal Chemistry Division of the Italian Chemical Society
Rui MOREIRA – Member of the Executive Committee of the European Federation for Medicinal Chemistry
Marco MACCHIA– Director of the European School of Medicinal Chemistry

“Medicinal chemistry approaches in personalized medicines”

Co-chair:
Andrea CAVALLI – University of Bologna (I)
Stefania BUTINI – University of Siena (I)

09.20 – 09.30

Introduction to the Session

09.30 – 10.15

Pier Giuseppe PELICCI – Istituto Europeo di Oncologia – Milan (I)
Introductory overview on precision medicine

10.15 – 11.00

Marinella ROBERTI – University of Bologna (I)
Synthetic lethality as a new paradigm for the development of anticancer agents

11.00 – 11.30

Coffee Break

11.30 – 12.15

Emanuele GABELLIERI – AC Immune SA, Lausanne (CH)
Discovery of novel PET tracer for the detection of pathological tau aggregated: Towards precision medicine in neurodegenerative diseases

12.15 – 13.00

Alan P. KOZIKOWSKI – StarWise Therapeutics LLC, Madison, WI (USA)
Urea-based prostate specific membrane antigen (PSMA) ligands for the diagnosis and therapy (theranostic) of prostate cancer

13.00 – 15.00

Lunch

15.00 – 17.30

Case Studies
Marinella ROBERTI – University of Bologna (I)
Development of synthetic lethal candidate leads 

Emanuele GABELLIERI – AC Immune SA (Lausanne, CH)
Design of a suitable PET ligand(s) and the respective precursor(s) starting from the proposed structures

20.30

Dinner

“Continuous flow chemistry in drug discovery and development”

Co-chair:
Paolo GRIECO – University of Naples Federico II (I)
Tracey PIRALI – University of Piemonte Orientale (I)

09.00 – 09.15

Introduction to the Session

09.15 – 10.00

Andreas KIRSCHNING – Leibniz University of Hannover (D)
Enabling Technologies in Organic Synthesis of Drugs – On Minireactors and Inductive Heating

10.00 – 10.45

Antimo GIOIELLO – University of Perugia (I)
Medicinal chemistry powered by continuous flow technology – a multifaceted toolbox for compound library building and scale-up processes

10.45 –11.15

Coffee Break

11.15 – 12.00

Marcus BAUMANN – University College Dublin (IRL)
Continuous flow chemistry for readily scaled routes into drug-like entities

12.00 – 12.45

Giorgio MARINI – CEM s.r.l., Cologno al Serio, BG (I)
Use of microwave technology in different synthetic applications

12.45 – 14.30

Lunch

14.30 – 18.00

Workshop
Bruno CERRA – University of Perugia (I)
Andrew MANSFIELD and Marco GRASSO – SYRRIS 

Workshop: Giorgio MARINI – CEM

20.30

Dinner

“Reducing drug attrition rate: predictive PK and ligand residence time”

Co-chair:
Fabrizio MICHELI – Aptuit S.r.l. – Verona (I)
Antonio MACCHIARULO – University of Perugia (I)

09.00 – 09.15

Introduction to the Session

09.15 – 10.00

Gerard ECKER – University of Vienna (A)
Predicting Ligand Residence Time – it’s all about how long you stay

10.00 – 10.45

Valerio MAMMOLI – Aptuit S.r.l. – Verona (I)
Optimizing DMPK Properties: The role of pharmacokinetics in drug discovery

10.45 – 11.15

Coffee Break

11.15 – 12.00

Gabriele CRUCIANI – University of Perugia (I)
Personalized approaches to clinical trials

12.00 – 12.45

Ismael ZAMORA – Lead Molecular Design S.L. (ES)
How structure elucidation of reactive metabolites can help in the toxicity prediction

12.45 – 14.30

Lunch

14.30 – 16.30

Workshop
Molecular Discovery Ltd, London (UK)

20.30

Gala Party

09.00 – 10.00

Tiziano BANDIERA – Istituto Italiano di Tecnologia – Genova (I)
Market Watch: New Drug Approvals in 2017 and Synthetic Strategies

Chairperson: Gilberto SPADONI – University of Urbino (I)
Selected oral lectures

Federica DALL’OGLIO – University of Milan (I)
Biocatalyzed continuous-flow processes and their application in the synthesis of active pharmaceutical ingredients

Serena DELLA VOLPE – University of Pavia (I)
Towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modeling approach for the exploration of ligand binding modes

Anna Corbera DURAN – Institute for Advanced Chemistry of Catalonia, Barcelona (E)
Photo-cardiac modulation without requirement for genetic manipulation using synthetic light-regulated drugs

Nicolò FANTONI – Dublin City University (IRL)
Artificial metallo-nucleases for gene editing

Mihaela JURKOVIĆ – Fidelta Ltd, Zagreb (HR)
A new Class of the hedgehog signalling pathway modulators

Nicola LUISE – University of Dundee (UK)
To design and develop semi-saturated bicyclic heterocycles for fragment-based drug discovery (FBDD) campaigns

Marco MACCHIA – University of Pisa (I) – ESMEC Director
Awards of Selected Posters
Concluding Remarks

13.15

Lunch and leaving

15.00 – 17.00

Tavola rotonda: 

Aspetti e opportunità dei progetti Europei 

18.00

Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI