SUNDAY, JUNE 30
15.00 – 18.30 Registration
19.00 – 22.00 Putting up of Posters and Dinner
MONDAY, JULY 1
09.00 – 09.20 Opening of ESMEC 2024
Giorgio CALCAGNINI – Rector of the University of Urbino Carlo Bo
Luc VAN HIJFTE – President of the European Federation for Medicinal Chemistry and Chemical Biology
Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society
Marco MACCHIA – Director of the European School of Medicinal Chemistry
MAKE IT UNBREAKABLE! COVALENT APPROACH IN DRUG DISCOVERY
Co-chair: Andrea CAVALLI – University of Bologna (I)
Gianluca PAPEO – Nerviano Medical Sciences (I)
09.20 – 09.30 Introduction to the Session
09.30 – 10.15 Alessio LODOLA – University of Parma (I)
Models for the discovery of covalent inhibitors
10.15 – 11.00 Chiara BORSARI – University of Milan (I)
Integration of medicinal chemistry and chemical biology in the development of covalent
chemical probes
11.00 – 11.30 Coffee Break
11.30 – 12.15 Annamaria MARTORANA – University of Palermo (I)
Targeting Sars-Cov-2 Main protease in the treatment of COVID-19: focus on covalent
inhibition
12.15 – 13.00 Francesco CASUSCELLI – Nerviano Medical Sciences, Milan (I)
Leveraging Covalent Approaches for the Discovery and Drug Development of Dual
IDH1/2 Second Generation Inhibitors
13.00 – 15.00 Lunch
15.00 – 17.00 Workshop: PICK YOUR FAVORITE ELECTROPHILE! FROM REACTIVITY SCALE TO COVALENT ADDUCT STRUCTURES
Chiara BORSARI – University of Milan (I)
Alessio LODOLA – University of Parma (I)
17.00 – 18.00 Poster Session
Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
20.00 Dinner
21.00 Walking tour of the historic center of Urbino, UNESCO heritage site
TUESDAY, JULY 2
CLICK-AND-TAG: HOW BIOORTHOGONAL CHEMISTRY IS TRANSFORMING DRUG DISCOVERY
Co-chair: Stephanie FEDERICO – University of Trieste (I)
Antimo GIOIELLO – University of Perugia (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Helen OSBORN – University of Reading (UK)
Designing chemical reactions for use in living systems: the role of bioorthogonal chemistry
10.00 – 10.45 Anja PALMANS – Eindhoven University of Technology (NL)
Bioorthogonal catalysis for medicinal chemistry applications
10.45 – 11.15 Coffee Break
11.15 – 12.00 Frédéric TARAN – Paris-Saclay University (F)
In vivo chemistry for diagnostic and therapeutic applications
12.00 – 12.45 Milan VRABEL – Czech Academy of Sciences, Prague (CZ)
Developing new bioorthogonal reactions: Expanding the toolbox for biomedical research
12.45 – 14.30 Lunch
14.30 – 16.00 Workshop: HOW TO TRANSLATE MEDCHEM DISCOVERIES INTO INNOVATION
Elisabetta Zaccaro – Notarbartolo & Gervasi, Milan (I)
Marco Borgogno – IAMA Therapeutics, Genoa (I)
16.00 Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI
17.00 – 18.00 Poster Session
Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
19.45 Dinner
21.00 Guided tour of the Ducal Palace
WEDNESDAY, JULY 3
UNUSUAL ELEMENTS AND FUNCTIONAL GROUPS SHAPING THE FUTURE OF MEDICINAL CHEMISTRY
Co-chair: Paolo GRIECO – University of Naples Federico II (I)
Tracey PIRALI – University of Piemonte Orientale (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Gian Cesare TRON – University of Piemonte Orientale (I)
Lost and found: (Re)discovering the potential of neglected functional groups in medicinal chemistry. A focus on isocyanides
10.00 – 10.45 Jack ROWBOTHAM – University of Manchester (UK)
Meeting the challenges of heavy drug synthesis with biocatalytic asymmetric deuteration
10.45 – 11.15 Coffee Break
11.15 – 12.00 Evamarie HEY-HAWKINS – Leipzig University (D)
Carborane-containing drugs: New keys for old locks
12.00 – 12.45 Mauro ADAMO – University of Medicine and Health Science, Dublin (IE)
Introduction of fluorine on small and large molecules: Opportunities for drug discovery and lead development
12.45 – 14.30 Lunch
14.30 – 17.00 Round Table: The Future of Medicinal Chemistry: the opinion of emerging voices (Open Webinar)
Chairperson: Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society
Participants: Chiara BORSARI – Università degli Studi di Milano (I)
Matthias GEHRINGER – Eberhard Karls Universität Tübingen (D)
Luca LARAIA – Technical University of Denmark (DE)
Sebastian OEHLER – Philochem AG (CH)
Andrea TESTA – Amphista Therapeutics Limited (UK)
Beatriz DE PASCUAL-TERESA – University CEU San Pablo, Madrid (E)
17.00 – 17.30 Fourth Edition of the ESMEC Alumni Award (Open Webinar)
Chairperson: Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society
20.30 Social Dinner
THURSDAY, JULY 4
Chairperson: Beatriz DE PASCUAL-TERESA, University CEU San Pablo, Madrid (E)
09.00 – 10.00 Tiziano BANDIERA – Istituto Italiano di Tecnologia, Genoa (I)
Market watch: new drug approval in 2023 and synthetic strategies
10.00 – 10.30 Coffee Break
10.30 – 10.45 Michele MARI – University of Urbino Carlo Bo (I)
EFMC-YSN: join the young scientists network!
10.45 – 12.45 Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
Selected oral lectures by participants:
Cosentino Giuseppe, University of Catania
Cursaro Ilaria, University of Siena
Giannessi Lisa, University of Parma
Lammers Rob F., Leiden University, NL
Madruga Enrique, University Computense Madrid
Masoni Samuele, University of Pisa
Persico Margherita, University of Trieste
12.45 – 13.15 Marco MACCHIA – University of Pisa (I) – Director of ESMEC
Awards of selected posters
Concluding remarks
13.15 Lunch and leaving