MONDAY, JUNE 28
09.00 – 09.20 Opening of ESMEC 2021
Giorgio CALCAGNINI – Rector of the University of Urbino Carlo Bo
Rui MOREIRA – President of the European Federation for Medicinal Chemistry
Gianluca SBARDELLA – President of the Medicinal Chemistry Division of the Italian Chemical Society
Marco MACCHIA – Director of the European School of Medicinal Chemistry
PROTEOLYSIS TARGETING CHIMERA (PROTAC): FROM MEDICINAL CHEMISTRY TO CLINICAL TRIALS
Morning Session
Co-chair: Gianluca PAPEO – Nerviano Medical Sciences (IT)
Tracey PIRALI – University of Piemonte Orientale (IT)
09.20 – 09.30 Introduction to the Session
09.30 – 10.15 Alessio CIULLI – University of Dundee (UK)
Targeted protein degradation with small molecules: How PROTACs work
10.15 – 11.00 Peter ETTMAYER – Boehringer Ingelheim, Wien (AT)
Lessons learned with co-operativity driven and structure guided PROTAC design
11.00 – 11.15 Break
11.15 – 12.00 Michael GÜTSCHOW – University of Bonn (DE)
Towards the Development of PROTACs for the Degradation of CDK6 and Beyond
12.00-12.45 Danilo MIRIZZI – Nerviano Medical Sciences (IT)
The PROTAC challenge
Afternoon Session
15.00 – 17.30 Open Webinar
Round Table: Covid and Science
Chairman: Gianluca SBARDELLA – President of the Medicinal Chemistry Division of the Italian Chemical Society (IT)
Participants: Rui MOREIRA – President of the European Federation for Medicinal Chemistry and Chemical Biology (PT)
Gabriele COSTANTINO – Director of the Department of Food and Drugs, University of Parma; Vice-President of the Italian Chemical Society (IT)
Emanuele ANDREANO – Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena (IT)
Nir LONDON – Weizmann Institute of Science, Rehovot (IL), COVID Moonshot initiative
Armando GENAZZANI – University of Piemonte Orientale, (IT); Technical and Scientific Committee of the Italian Medicines Agency (AIFA); Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA)
Giovanni MAGA – Director of Institute of Molecular Genetics IGM-CNR, Head of the DNA Enzymology&Molecular Virology Section, National Research Council, Pavia (IT)
18.00 – 18.45 Nello MAINOLFI – Kymera Therapeutics, Cambridge (USA)
Targeted Protein Degradation Beyond Oncology
TUESDAY, JUNE 29
Morning Session
SUSTAINABLE CHEMISTRY APPROACHES TO LEAD DISCOVERY AND CHEMICAL PROCESSES
Co-chair: Stefania BUTINI – University of Siena (IT)
Antonio MACCHIARULO – University of Perugia (IT)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Maurizio TADDEI – University of Siena (IT)
Streamlined synthetic design for a sustainable access to active pharmaceutical
ingredients
10.00 – 10.45 Irini ABDIAJ – Janssen Cilag S.A., Toledo (ES)
Continuous Flow in Medicinal Chemistry: opening new chemical space for Drug
Discovery
10.45 – 11.00 Break
11.00 – 11.45 Fabrizio MICHELI – Aptuit S.r.l. – An Evotec Company, Verona (IT)
Dopamine D3 antagonists with modified “amino” region: developability aspects
11.45 – 12.30 Luca DELL’AMICO – University of Padua (IT)
Disclosing the Synthetic Potential of Light-Excited Ketones – from the Concepts towards Sustainable Applications
Afternoon Session
15.00 – 17.00 Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (IT)
Poster Session
17.00 – 18.00 Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI
18.00 Social Event
WEDNESDAY, JUNE 30
MEDICINAL CHEMISTRY’S RESPONSE TO THE BURDEN OF ANTIBIOTIC RESISTANCE
Morning Session
Co-chair: Andrea CAVALLI – University of Bologna (IT)
Paolo GRIECO – University of Naples (IT)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Marialuisa MANGONI – Sapienza University of Rome (IT)
A lesson from amphibian skin antimicrobial peptides and derivatives for new therapeutic application
10.00 – 10.45 Marc DEVOCELLE – Royal College of Surgeons in Ireland, Dublin (IE)
Covalent modification of Antimicrobial Peptides
10.45 – 11.00 Break
11.00 – 11.45 Marco DE VIVO – Istituto Italiano di Tecnologia – Genoa (IT)
Mechanistic insights into bacterial group II intron RNA catalysis
11.45 – 12.30 Syma KHALID – University of Southampton (UK)
Molecular Dynamics simulations reveal unexpected details of antibiotic interactions
within bacterial cell envelopes
Afternoon Session
15.00 – 17.00 Open Webinar
Celebration of the 40th Anniversary of the School
Chairman: Marco MACCHIA – Director of the European School of Medicinal Chemistry
First edition of the ESMEC Alumni Award
Chairman: Gianluca SBARDELLA– President of the Medicinal Chemistry Division – SCI
THURSDAY, JULY 1
Chairperson: Antoni TORRENS, Welab, Barcelona (ES)
09.00 – 10.00 Tiziano BANDIERA – Istituto Italiano di Tecnologia – Genoa (IT)
Market Watch: New Drug Approval in 2020 and Synthetic Strategies
10.00 – 10.15 Break
10.15 – 12.15 Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (IT)
Selected oral lectures by participants
Bonnet Maurinne – ICN, Nizza
Cecchini Carlotta – University of Geneva
Introvigne Maria Luisa – University of Modena e Reggio Emilia
Martí Marí Olaia – Medicinal Chemistry Institute – CSIC
Palomba Tommaso – University of Perugia
Vrettos Erinaios – University of Ioannina
12.15 – 13.00 Marco MACCHIA – Director of the European School of Medicinal Chemistry
Awards of selected posters
Concluding remarks