SUNDAY, JULY 3
15.00 – 18.30 Registration
19.00 – 22.00 Putting up of Posters and Dinner
MONDAY, JULY 4
09.00 – 09.20 Opening of ESMEC 2022
Giorgio CALCAGNINI – Rector of the University of Urbino Carlo Bo
Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society
Rui MOREIRA President of the European Federation for Medicinal Chemistry
Marco MACCHIA – Director of the European School of Medicinal Chemistry
NEW MODALITIES FOR TARGETING CHALLENGING PROTEINS
Co-chair: Gianluca PAPEO – Nerviano Medical Sciences (I)
Tracey PIRALI – University of Piemonte Orientale (I)
09.20 – 09.30 Introduction to the Session
09.30 – 10.15 Stefan KNAPP – Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt (D)
Selective degradation of protein targets as a new modality in drug development
10.15 – 11.00 Andrew PIKE – AstraZeneca, Cambridge (UK)
Optimising proteolysis targeting chimeras (PROTACs) for oral drug delivery: A drug metabolism and pharmacokinetics perspective
11.00 – 11.30 Coffee Break
11.30 – 12.15 Cristina MAYOR-RUIZ – Institute for Research in Biomedicine, Barcelona (E)
Scalable strategies to identify molecular glue degraders
12.15 – 13.00 Pietro PICCONI – Nerviano Medical Sciences, Nerviano (I)
The fast-moving field of targeted protein degradation: examples from literature
13.00 – 15.00 Lunch
15.00 – 18.00 Workshop: VIRTUAL REALITY IN MEDICINAL CHEMISTRY
Paolo GRIECO – University of Naples (I)
Andrea CAVALLI – University of Bologna (I)
Giovanni BOTTEGONI – University of Urbino (I)
20.00 Dinner
TUESDAY, JULY 5
ELECTROCHEMISTRY IN DRUG DISCOVERY
Co-chair: Antimo GIOIELLO, University of Perugia (I)
Paolo GRIECO – University of Naples Federico II (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Massimo MARCACCIO – University of Bologna (I)
Electrochemistry as a challenging tool for reaction mechanisms and chemical synthesis
10.00 – 10.45 Kevin LAM – University of Greenwich (UK)
Anodic oxidations of carboxylic acids in batch and flow: new tricks for an old reaction
10.45 –11.15 Coffee Break
11.15 – 12.00 Lutz ACKERMANN – Georg-August-University of Göttingen (D)
Metallaelectro-catalyzed bond activations
12.00 – 12.45 Nessa CARSON – Syngenta, Bracknell (UK)
Industrial electrochemistry: from screening to scaleup
12.45 – 14.30 Lunch
14.30 – 16.00 Workshop: EXPERIENCING ELECTROCHEMISTRY co-organized with IKA Werke GmbH & Co., Staufen (D)
Antimo GIOIELLO, University of Perugia (I)
16.00 – 18.00 Poster Session
Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
18.00 Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI
19.45 Dinner
21.00 Guided tour of the Ducal Palace
WEDNESDAY, JULY 6
RARE DISEASES AND ORPHAN DRUGS
Co-chair: Andrea CAVALLI – University of Bologna (I)
Stephanie FEDERICO – University of Trieste (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Francesco MACCHIA – Rare-Lab, Osservatorio Farmaci Orfani, Roma (I)
Ethics and opportunities in rare diseases research
10.00 – 10.45 Armando GENAZZANI – University of Piemonte Orientale (I)
From regulatory and reimbursement frameworks to proof-of-principle animal models, including a personal recollection of tubular aggregate myopathy
10.45 – 11.15 Coffee Break
11.15 – 12.00 Gijs VAN HAAFTEN – Utrecht University (NL)
Towards treatment of Cantu syndrome: drug repurposing for a rare disease
12.00 – 12.45 Angela RUSSELL – University of Oxford (UK)
Development of next generation utrophin modulators for duchenne muscular dystrophy: learning from clinical setbacks
12.45 – 14.30 Lunch
14.30 – 17.00 Round Table: Covid and Science (Open Webinar)
17.00 – 17.30 Second Edition of the ESMEC Alumni Award (Open Webinar)
20.30 Social Dinner
THURSDAY, JULY 7
Chairperson: Antoni TORRENS – Welab, Barcelona (E)
09.00 – 10.00 Tiziano BANDIERA – Istituto Italiano di Tecnologia – Genoa (I)
Market watch: new drug approval in 2021 and synthetic strategies
10.00 – 10.30 Coffee Break
10.30 – 12.30 Chairperson: Gilberto SPADONI – University of Urbino Carlo Bo (I)
Selected oral lectures by participants:
1) Annunziata Francesca – University of Milan
2) Bhela Irene Preet – University of Piemonte Orientale
3) Demuro Stefania – University of Bologna
4) Felix Rita – University of Lisbon (P)
5) Pedrola Marina – University of Barcelona (E)
6) Wojtczak Karolina – National University of Ireland (IRL)
12.30 – 13.15 Marco MACCHIA – University of Pisa (I) – Director of ESMEC
Awards of selected posters
Concluding remarks
13.15 Lunch and leaving