SUNDAY, JULY 2

15.00 – 18.30 Registration
19.00 – 22.00 Putting up of Posters and Dinner

 

MONDAY, JULY 3

09.00 – 09.20

 

Opening of ESMEC 2023
Giorgio CALCAGNINI – Rector of the University of Urbino Carlo Bo
Rui MOREIRA – President of the European Federation for Medicinal Chemistry and Chemical Biology
Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society
Marco MACCHIA – Director of the European School of Medicinal Chemistry

  
  PHARMACOMICROBIOMICS: THE COMPLEX WORLD OF DRUG-MICROBIOME INTERACTIONS  
Co-chair:

Paolo GRIECO, University of Naples Federico II (I)

Andrea CAVALLI, University of Bologna (I)

  
09.20 – 09.30

 

Introduction to the Session

  
09.30 – 10.00

Francesca LEMBO, University of Naples Federico II (I)

The microbiome-drug metabolism axis. The implication of pharmacomicrobiomics in neuropharmacology

  
10.00 – 10.30

Silvia TURRONI, University of Bologna (I)

Pharmacomicrobiomics in anticancer therapies

  
10.30 – 11.00

Saskia VAN MIL, Center for Molecular Medicine, UMC Utrecht (NL)

Host-microbiome interplay in bile acid metabolism; implications for therapeutic strategies targeting metabolic disease

  
11.00 – 11.30 Coffee Break

 

 
11.30 – 13.00 Workshop: EXTENDED VIRTUAL REALITY IN MEDICINAL CHEMISTRY
Roberta Bartolotta, Nanome, San Diego (USA)		  
13.00 – 15.00 Lunch  
15.00 – 17.00

 

Round Table: Harnessing the power of medicinal chemistry to develop new therapies: Inspiring Success Stories (Open Webinar)

  

 

Chairperson:

 

Participants:

 

 

 

 

Maria Laura BOLOGNESI – President of the Medicinal Chemistry Division of the Italian Chemical Society

Monica BINASCHI – Global Director, Preclinical and Translational Sciences, Menarini Ricerche, Firenze (I)
Matilda BINGHAM – Chief Scientific Officer, Concept Life Sciences, Manchester (UK)
Rui MOREIRA – President of the European Federation for Medicinal Chemistry and Chemical Biology
Vincenzo SUMMA – Full professor, University of Naples Federico II (I)
Antoni TORRENS – ABAC Therapeutics S.L., Barcelona (E)

  
17.00 – 18.00

Poster Session

Chairperson: Gilberto SPADONI – University of Urbino (I)

  
20.00 Dinner  

TUESDAY, JULY 4

  MECHANOCHEMISTRY: A SUSTAINABLE TOOL TO NAVIGATE THE UNCHARTED CHEMICAL SPACE
Co-chair:

Antimo GIOIELLO, University of Perugia (I)

Stephanie FEDERICO, University of Trieste (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Tomislav FRIŠČIĆ, University of Birmingham (UK) Medicinal mechanochemistry: Opportunities for solid form screening and reaction discovery
10.00 – 10.45

Evelina COLACINO, University of Montpellier (F)

Mechanochemistry towards green pharmaceuticals
10.45 –11.15 Coffee Break
11.15 – 12.00

Duncan BROWNE, School of Pharmacy, London (UK)

Making Medicinal Molecules by Mechanochemically Manipulating Metals
12.00 – 12.45

Lucia MAINI, University of Bologna (I)

From unexpected to desired reactions: how mechanochemistry  can change your research
12.45 – 14.30 Lunch
14.30 – 17.00

Workshop: EXPERIENCING MECHANOCHEMISTRY co-organized with Verder-scientific.

Andrea PORCHEDDU, University of Cagliari (I)
17.00 – 18.00

Poster Session

Chairperson: Gilberto SPADONI – University of Urbino (I)

 
18.00 Assemblea della Sezione Giovani della Divisione di Chimica Farmaceutica  della SCI
19.45 Dinner
21.00 Guided tour of the Ducal Palace

 

 

WEDNESDAY, JULY 5

  PREVENTING THE TURN! ATROPISOMERISM IN DRUG DISCOVERY
Co-chair:

Tracey PIRALI, University of Piemonte Orientale (I)

Gianluca PAPEO, Nerviano Medical Science (I)

 
09.00 – 09.15 Introduction to the Session
09.15 – 10.00

José M. LASSALETTA, Centro de Innovaciónen Química Avanzada, Sevilla (E),

Dynamic Resolution Strategies for the Atroposelective Synthesis of Axially Chiral (Hetero)biaryls
10.00 – 10.45

Anna-Carin C. CARLSSON, AstraZeneca Gothenburg, Molndal (S)

Synthetic strategies and challenges for manufacturing atropisomeric KRASG12C inhibitors for use in preclinical studies
10.45 – 11.15 Coffee Break
11.15 – 12.00

Silvia CAPACCHI, Chiesi Farmaceutici SpA, Parma (I)  

The Atropisomerism Challenge in Drug Discovery: the role of NMR
12.00 – 12.45

Thomas FUCHSS, Merck KGaA, Darmstadt (D),

M3541 and M4076 – Discovery and Optimization of Potent and Selective ATM Kinase Inhibitors with Strong Anti-tumor Efficacy in Combination Therapies
12.45 – 14.30 Lunch
14.30 – 17.00 Workshop: ARTIFICIAL INTELLIGENCE BASED RETROSYNTHESIS
  Teodoro LAINO, IBM Research Zurich (CH)
17.00 – 17.30 III Edition of the ESMEC Alumni Award (Open Webinar)
20.30 Social Dinner
   

 

THURSDAY, JULY 6

 

Chairperson:

Antoni TORRENS – ABAC Therapeutics S.L., Barcelona (E)
09.00 – 10.00

Tiziano BANDIERA – Istituto Italiano di Tecnologia – Genoa (I)

Market Watch: New Drug Approvals in 2022 and Synthetic Strategies

 
10.00 – 10.30 Coffee break
10.30 – 10.45

Michele Mari, University of Urbino (I)

“EFMC-YSN: Join the Young Scientists Network!”
10.45 – 12.45

Chairperson: Gilberto SPADONI – University of Urbino (I)

Selected oral lectures by participants

1) Aguado Fernandez David, University of Strathclyde
2) Bellina Francesco, IIT/University of Genova
3) Bianconi Elisa, University of Perugia
4) Brunelli Francesca, University of Piemonte Orientale
5) Di Stefano Miriana, University of Siena
6) Regni Alessio, University of Urbino

 
12.45 – 13.15

Marco MACCHIA – University of Pisa (I) – Director of ESMEC

Awards of Selected posters

Concluding remarks
13.15 Lunch and leaving