SUNDAY, JULY 2

15.00 – 18.30 Registration at “Collegio Internazionale” Piazza San Filippo 2, Urbino
19.00 – 22.00 Putting up of posters at “Palazzo Battiferri”, Via Saffi 42, Urbino and Buffet dinner at the restaurant “Il Castello”, Via del Poggio, Urbino

MONDAY, JULY 3

09.00 – 09.20 Opening of ESMEC 2017
Gabriele COSTANTINO – President of the Medicinal Chemistry Division of the Italian Chemical Society
Rui MOREIRA – Member of the EFMC Executive Committee
Polypharmacology and Multi-targeting paradigms in drug discovery: complexity against complexity
Co-chair:
Maria Laura BOLOGNESI – University of Bologna (I)
Stefania BUTINI – University of Siena (I)
09.20 – 09.30 Introduction to the session
09.30 – 10.15 Rona R. RAMSAY – University of St Andrews – St Andrews (UK)
Designing monoamine oxidase inhibitors in multi-target drugs to address neuropathology
10.15 – 11.00 Christophe ROCHAIS – Université de Caen Normandie – Caen (F)
Modulating 5-HTS receptors in alzheimer’s disease treatment: a polypharmacology approach
11.00 – 11.30 Coffee Break
11.30 – 12.15 Maria Fernanda BORGES – University of Porto (P)
Neurodegenerative diseases and therapy: challenges and opportunities
12.15 – 13.00 Holger Stark – Heinrich-Heine-University, Duesseldorf (D)
Multiple Targeting with Histamine H3 Receptor Ligands
13.00 – 15.00 Lunch
15.00 – 16.00 Case Study, Serena Tongiani – Angelini SpA – Pomezia, I
Novel Approaches to Drug Design and Development: Case Studies in Molecular Structure, Computation, Ligand-Receptor Interaction and Modelling
16.00 – 17.30 Case Study,  Christophe Rochais , Université de Caen Normandie – Caen (F)
Polypharmacology in Drug Discovery
20.30 Dinner

TUESDAY, JULY 4

Structures and models in drug design
Co-chair:
Antonio MACCHIARULO – University of Perugia (I)
Marco MOR – University of Parma (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Gerhard HESSLER – Sanofi-Aventis Deutschland GmbH – Frankfurt (D)
Successful structure-based drug design – A case study
10.00 – 10.45 Giulio VISTOLI – University of Milan (I)
From molecular docking to virtual screening approaches: an in silico travel poking around the recognition event
10.45 – 11.15 Coffee Break
11.15 – 12.00 Pierre Ducrot – Institut de Recherches Servier – Suresnes (F)
Predicting ligand-target residence time using Smoothed-Molecular Dynamics
12.00 – 12.45 Giovanni BOTTEGONI – Heptares Therapeutics, Welwyn Garden City (UK)
Computer-assisted design of multi-target compounds
12.45 – 14.30 Lunch
14.30 – 16.00 Case study, Sergio Decherchi, Biki Technologies – Genoa, I
16.00 – 18.00 Mini-workshop, Andrea Ciacci, S-IN – Vicenza, I
20.30 Dinner

WEDNESDAY, JULY 5

Peptides: from synthesis to applications
Co-chair:
Fabrizio MICHELI – Aptuit S.r.l. – Verona (I)
Giampiero SPALLUTO – University of Trieste (I)
09.00 – 09.15 Introduction to the Session
09.15 – 10.00 Paolo ROVERO – University of Florence (I)
From the discovery of solid-phase synthesis to the development of new drugs: half a century of peptide chemistry from the viewpoint of a medicinal chemist
10.00 – 10.45 Paolo GRIECO – Federico II University– Neaples (I)
From Peptides to Peptidomimetics: Design and Synthesis of Potential Drug
10.45 – 11.15 Coffee Break
11.15 – 12.00 Jeffrey W. BODE – ETH – Zurich (CH)
Chemical Protein Synthesis, the KAHA Ligation
12.00 – 12.45 Fernando FORMAGGIO – University of Padua (I)
Synthesis, conformation and bioactivity of selected peptaibiotics
12.45 – 14.30 Lunch
14.30 – 16.30 Case Study, Francesca Benevelli, Bruker Italia – Milan, I
16.30 – 18.00 Chairperson: Gilberto SPADONI – University of Urbino (I)
Poster Session
20.30 Gala Party

THURSDAY, JULY 6

Beyond PhD: building up an appealing scientific and professional profile
Co-chair:
Rui MOREIRA – University of Lisbon (P)
Gilberto SPADONI – University of Urbino (I)
09.00 – 10.30 Donna HURYN – University of Pittsburgh (USA)
The publishing Process
10.30 – 10.50 Coffee Break
10.50 – 12.50 Selected oral lectures by participants :

  1. Alfano  Gloria – University of Siena
  2. Callegari Donatella – University of  Parma
  3. Carvalho Luís – University of Lisbon
  4. Castro Guilherme – University of Dundee
  5. Lazić Jelena –  University of Belgrade
  6. Sighel Denise – University of Trento
12.50 – 13.10 Chairperson: Maria Laura BOLOGNESI – University of Bologna (I)
ACS award of selected posters
13.10 Concluding Remarks
13.30 Lunch and Leaving

PARALLEL EVENTS
TUESDAY, JULY 4

15.00 – 17.00 Tavola rotonda
La chimica farmaceutica ed i corsi di dottorato: prospettive ed opportunità
18.30 Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI