SUNDAY, JULY 1

 

15.00 – 18.30

Registration

19.00 – 22.00

Putting up of Posters and Dinner

 

MONDAY, JULY 2

09.00 – 09.20

Opening of ESMEC 2018
Marco MACCHIA– Director of ESMEC

Gabriele COSTANTINO – President of the Medicinal Chemistry Division – SCI
Rui MOREIRA – Member of the EFMC Executive Committee

“Medicinal chemistry approaches in personalized medicines”

Co-chair:
Andrea CAVALLI – University of Bologna (I)
Stefania BUTINI – University of Siena (I)

09.20 – 09.30

Introduction to the Session

09.30 – 10.15

Giuseppe PELLICCI – Istituto Europeo di Oncologia – Milan (I)
Introductory overview on precision medicine

10.15 – 11.00

Marinella ROBERTI – University of Bologna (I)
Synthetic lethality as a new paradigm for the development of anticancer agents

11.00 – 11.30

Coffee Break

11.30 – 12.15

Emanuele GABELLIERI – AC Immune SA, Lausanne (CH)
Discovery of novel PET tracer for the detection of pathological tau aggregated: Towards precision medicine in neurodegenerative diseases

12.15 – 13.00

Alan P. KOZIKOWSKI – StarWise Therapeutics LLC, Madison, WI (USA)
Epigenetics, Chemistry, and Biology – Histone Deacetylase Inhibitors for Neurological Disorders

13.00 – 15.00

Lunch

15.00 – 17.30

Case Studies: Marinella ROBERTI – University of Bologna (I) 
                        Emanuele GABELLIERI – AC Immune SA (Lausanne, CH)

20.30

Dinner

 

TUESDAY, JULY 3

 

“Continuous flow chemistry in drug discovery and development”

Co-chair:
Paolo GRIECO – University of Naples Federico II (I)
Tracey PIRALI – University of Piemonte Orientale (I)

09.00 – 09.15

Introduction to the Session

09.15 – 10.00

Andreas KIRSCHINING – Leibniz University of Hannover (D)
Enabling Technologies in Organic Synthesis of Drugs – On Minireactors and Inductive Heating

10.00 – 10.45

Antimo GIOIELLO – University of Perugia (I)
Medicinal chemistry powered by continuous flow technology – a multifaceted toolbox for compound library building and scale-up processes

10.45 –11.15

Coffee Break

11.15 – 12.00

Marcus BAUMANN – University College Dublin (IRL)
Continuous flow chemistry for readily scaled routes into drug-like entities

12.00 – 12.45

Giorgio MARINI – CEM Europe
Use of microwave technology in different synthetic applications

12.45 – 14.30

Lunch

14.30 – 18.00

Workshop: Bruno CERRA – University of Perugia (I), Andrew MANSFIELD and Marco GRASSO – SYRRIS 

Workshop: Giorgio MARINI – CEM

20.30

Dinner

 

WEDNESDAY, JULY 4

“Reducing drug attrition rate: predictive PK and ligand residence time”

Co-chair:
Fabrizio MICHELI – Aptuit S.r.l. – Verona (I)
Antonio MACCHIARULO – University of Perugia (I)

09.00 – 09.15

Introduction to the Session

09.15 – 10.00

Gerard ECKER – University of Vienna (A)
Predicting Ligand Residence Time – it’s all about how long you stay

10.00 – 10.45

Valerio MAMMOLI – Aptuit S.r.l. – Verona (I)
Optimizing DMPK Properties: The role of pharmacokinetics in drug discovery

10.45 – 11.15

Coffee Break

11.15 – 12.00

Gabriele CRUCIANI – University of Perugia (I)
Personalized approaches to clinical trials

12.00 – 12.45

Ismael ZAMORA – Lead Molecular Design S.L. (ES)
How structure elucidation of reactive metabolites can help in the toxicity prediction

12.45 – 14.30

Lunch

14.30 – 16.00

Tiziano BANDIERA – Istituto Italiano di Tecnologia – Genova (I)
Market Watch: New Drug Approval in 2017 and Synthetic Strategies

16.00 – 18.00

Chairperson: Gilberto SPADONI – University of Urbino (I)
Poster Session

20.30

Gala Party

 

THURSDAY, JULY 5

09.00

Selected oral lectures by participants

Awards of selected posters

13.00 

Concluding remarks

13.10

Lunch and leaving

 

 

PARALLEL EVENTS

TUESDAY, JULY 3

 

15.00 – 17.00

Tavola rotonda: 

Aspetti e opportunità dei progetti Europei 

18.30

Assemblea della sezione Giovani della Divisione di Chimica Farmaceutica della SCI